Recombinant full-length human CDK7 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tags.
Catalog No. C36-14G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C36-14G-20 | 20 ug | $215 | |
C36-14G-50 | 50 ug | $435 | |
C36-14G-BULK | BULK | Contact Us |
Overview:
CDK7 gene is a member of the cyclin-dependent protein kinase family that is important regulators of cell cycle progression (1). CDK7 forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). CDK7 is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair. CDK7 is thought to serve as a direct link between the regulation of transcription and the cell cycle (2).
Gene Aliases:
CDK7: CAK1, STK1, CDKN7, p39MO15
Genbank Number:
References:
1. Fisher, R. P.;A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 78: 713-724, 1994.
2. Larochelle, S. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Molec. Cell 25: 839-850, 2007.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66 kDa
M Kanke et al., Cohesin acetylation and Wapl-Pds5 oppositely regulate translocation of cohesin along DNA. EMBO Journal November 2016 10.15252/embj.201695756
Liu Haidan et al., A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases Journal of Biological Chemistry September 2013 10.1074/jbc.M113.464669
Cancer, Cell Cycle, Ser/Thr Kinases
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