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Anti 2019-nCoV N-Protein hIgG Antibody

Recombinant Human Monoclonal Antibody
Catalog No. C19NP-60H


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Catalog No. Pack Size Price (USD)
C19NP-60H-20 20 ug $165
C19NP-60H-100 100 ug $325
C19NP-60H-BULK BULK Contact Us  


Overview:

CoV N-Protein / Nucleocapsid protein is an RNA-binding protein primarily involved in binding to the viral RNA genome during packaging of viral RNA into a helical ribonucleoproteins or nucelocapsid structure (1). In addition, N-protein regulates viral RNA synthesis during replication/transcription and modulates host-pathogen interactions, such as actin reorganization, host cell cycle progression, and apoptosis (2). N-Protein is abundantly expressed during infection and antibodies against N-Protein have been detected in confirmed cases of Covid-19. Therefore, N-Protein is a potent antigen that provides basis for future vaccine and diagnostic kit development (3).

References:


1. McBride R, et al: The coronavirus nucleocapsid is a multifunctional protein. Viruses. 2014, 6:2991-3018.

2. Surjit M, et al: The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells. J Biol Chem. 2006, 281:10669-10681.

3. Zeng W, et al: Biochemical characterization of SARS-CoV-2 nucleocapsid protein. Biochem Biophys Res Commun. 2020, 527(3):618‐623.


Specificity :

Recognizes the 2019-nCoV N-Protein


Cross Reactivity:

SARS-CoV N-Protein


Host Isotype / Clone#:

Human IgG


Stability:

1yr at –20oC from date of shipment.


Assay Data:

Binding of Anti-2019-nCoV N-Protein Antibody (C19NP-60H) to immobilized 2019-nCoV N-Protein (C19NP-G242H) determined by ELISA using Goat anti-human Fc.


Western Blot:

Representative western blot of Anti-2019-nCoV N-Protein Antibody (C19NP-60H) (1:1000) using 1 µg of 2019-nCoV N-protein (C19NP-G242H).



Product Datasheets



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  Anti 2019-nCoV N-Protein hIgG Antibody, HRP conjugated, C19NP-60DH

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