Recombinant human ERK5 (1-398) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M32-15G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M32-15G-20 | 20 ug | $105 | |
M32-15G-50 | 50 ug | $160 | |
M32-15G-BULK | BULK | Contact Us |
Overview:
ERK5 is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. ERK5 is activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, ERK5 translocates to cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of ERK5 in mice results in defective blood vessel and cardiac development leading to embryonic lethality (1). ERK5 has been shown to be critical for endothelial function and maintenance of blood vessel integrity (2).
Genbank Number:
References:
1. Regan, C P. et al: Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc. Nat. Acad. Sci. 99: 9248-9253, 2002.
2. Hayashi, M. et al: Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J. Clin. Invest. 113: 1138-1148, 2004.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Alternative name(s):
MAPK7, BMK1, PRKM7
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~69 kDa. Calculated MW ~71 kDa.
There are no related publications available for this product.
Cell Cycle, ERK-Signaling pathway
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