Recombinant full-length human NFATC1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. N12-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
N12-30G-20 | 20 ug | $215 | |
N12-30G-50 | 50 ug | $435 | |
N12-30G-BULK | BULK | Contact Us |
Overview:
NFATC1 is a member of the NFAT family of proteins which are Ca2+/calcineurin-responsive transcription factors primarily recognized for their central roles in T lymphocyte activation and cardiac valve development (1). NFAT consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T-cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to the NFAT family of transcription factors play a central role in inducible gene transcription during immune response. The product of NFATC1 is an inducible nuclear component and functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A (2).
Gene Aliases:
NF-ATC; NFATc; NFAT2; MGC138448
Genbank Number:
References:
1. Buchholz, M. et al: Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO. J. 2006; 25(15):3714-24.
2. Jhun, B.S. et al: Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells. Biochem. Biophys. Res. Commun. 2006; 351(4):986-92.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~125 kDa
S. Alam Muhammad et al., Counter-regulation of T cell effector function by differentially activated p38 Journal of Experimental Medicine May 2014 10.1084/jem.20131917
Norrmen Camilla et al., FOXC2 Controls Formation and Maturation of Lymphatic Collecting Vessels through Cooperation with NFATc1 Journal of Cell Biology May 2009 10.1083/jcb.200901104
Ishiguro Kazuhiro et al., Cutting Edge: Tubulin α Functions as an Adaptor in NFAT-Importin β Interaction Journal of Immunology March 2011 10.4049/jimmunol.1003322
Egusaa Hiroshi et al., The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells Bone August 2011 10.1016/j.bone.2011.04.003
Cardiovascular Disease, Inflammation, JNK/SAPK Pathway, NfkB Pathway, p38 Pathway
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