Recombinant human DOCK5 SH3 domain (5-72) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. D50-35G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D50-35G-20 | 20 ug | $215 | |
D50-35G-50 | 50 ug | $435 | |
D50-35G-BULK | BULK | Contact Us |
Overview:
The Dedicator of Cytokinesis 5 (DOCK5) protein belongs to the DOCK family of guanine nucleotide exchange factors (GEFs) that play a crucial role in the regulation of Rho GTPases, particularly RhoA, Rac1, and Cdc42, which are pivotal in cellular signaling and cytoskeletal dynamics. The SH3 (Src homology 3) domain is a conserved protein module within DOCK5 that is implicated in protein-protein interactions and signaling pathways. The SH3 domain is a structurally conserved protein module, typically composed of about 50-70 amino acids, and is known to mediate protein-protein interactions through recognition of specific proline-rich motifs in binding partners. This domain plays a significant role in signaling pathways, cellular adhesion, and intracellular trafficking by facilitating the assembly of signaling complexes.
Genbank Number:
References:
1. Côté J-F, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol. 2007;17(8):383-393. doi:10.1016/j.tcb.2007.06.006
2. Meller N, Merlot S, Guda C. CZH proteins: a new family of Rho-GEFs. J Cell Sci. 2005;118(Pt 21):4937-4946. doi:10.1242/jcs.02642
3. Zhu J, et al. Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition. PLoS One. 2010;5(6):e11128. doi:10.1371/journal.pone.0011128
Alternative Name(s):
Dedicator of cytokinesis protein 5
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~36 kDa. Calculated MW ~34 kDa.
There are no related publications available for this product.
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