Recombinant mouse DNMT1 (766-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D351-31G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
D351-31G-20 | 20 ug | $215 | |
D351-31G-50 | 50 ug | $435 | |
D351-31G-BULK | BULK | Contact Us |
Overview:
DNMT1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities (1). DNMT1 enzyme is crucial for stable expression and function in vivo (2). DNMT1 is essential for maintenance of DNA methylation and the interaction of DNMT1 with the replication machinery is not strictly necessary for maintenance of DNA methylation, but improves its efficiency. DNMT1 is necessary and sufficient to maintain global methylation and aberrant CpG island methylation in human cancer cells.
Gene Aliases:
Dnmt; MCMT; Cxxc9; MTase; Met-1; Dnmt1o; m.MmuI; Met1; MommeD2
Genbank Number:
References:
1. Yoder, J. A. et.al: New 5-prime regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J. Biol. Chem. 271: 31092-31097, 1996.
2. Tucker, K. L. et.al: Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. Proc. Nat. Acad. Sci. 93: 12920-12925, 1996.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~132 kDa
There are no related publications available for this product.
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