UBE2Z(USE1) encodes the ubiquitin conjugating enzyme (E2) which is involved in Ubiquitination, the covalent attachment of the protein ubiquitin (Ub) to other cellular proteins (1). UBE2Z plays an important role in the ubiquitin process and has been implicated in a number of important physiological processes including apoptosis. UBE2Z is specifically charged with ubiquitin by UBA6 (2). UBE2Z is widely expressed in human tissues and expression is especially high in placenta, pancreas, spleen and testis.
1. Gu, X. et al: Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z). Mol Biol Rep. 2007 Sep;34(3):183-8.
2. Jin, J. et.al: Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature 447: 1135-1138, 2007.
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