UBE2H or ubiquitin-conjugating enzyme E2H is a member of the E2 ubiquitin-conjugating enzyme family which is located on chromosome 7 (1). UBE2H is known to act on histones and cytoskeletal proteins, both involved in the degenerative pathway of the motor neuron. UBE2H expression is increased during erythroid differentiation of hCD34(+) cells. Tal1 transcription factor, which is essential for the development of the hematopoietic system and plays a role during definitive erythropoiesis in the adult, activates UBE2H expression, whereas Tal1 knock-down reduced UBE2H expression and ubiquitin transfer activity (2).
E2-20K; UBC8; UBCH; UBCH2
1. Kaiser, P. et.al: Human ubiquitin-conjugating enzyme homologous to yeast UBC8. J. Biol. Chem. 269: 8797-8802, 1994.
2. Lausen J,Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. J Biol Chem. 2010 Feb 19;285(8):5338-46.
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Cancer, Cell Cycle, Neurobiology