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UBE2C, Active

Recombinant full-length human UBE2C was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U212-380H


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Catalog No. Pack Size Price (USD)
U212-380H-20 20 ug $215
U212-380H-50 50 ug $435
U212-380H-BULK BULK Contact Us  


Overview:

UBE2C or ubiquitin-conjugating enzyme E2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C acted as a dominant-negative inhibitor which blocks the destruction of mitotic cyclins A and B and the onset of anaphase in frog embryos and mammalian cells. High UBE2C mRNA expression is associated with poor disease-free survival and overall survival. High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C.


Gene Aliases:

dJ447F3.2; UBCH10


Genbank Number:


References:


1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016

2. Rape, M. et al: Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432: 588-595, 2004

3. Townsley, F. M. et al: Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc. Nat. Acad. Sci. 94: 2362-2367, 1997


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

21 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Neurobiology


RELATED PRODUCTS


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  UBA1 (UBE1), Active, U201-380G


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