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UBE2C, Active

Recombinant full-length human UBE2C was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U212-380H

Catalog No. Pack Size Price (USD)
U212-380H-20 20 ug $215
U212-380H-50 50 ug $435
U212-380H-BULK BULK Contact Us  


UBE2C or ubiquitin-conjugating enzyme E2C is a member of the E2 ubiquitin-conjugating enzyme family which is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C acted as a dominant-negative inhibitor which blocks the destruction of mitotic cyclins A and B and the onset of anaphase in frog embryos and mammalian cells. High UBE2C mRNA expression is associated with poor disease-free survival and overall survival. High tumor grade, as well as high Ki67 protein expression, was more frequent in the high-expression group of UBE2C.

Gene Aliases:

dJ447F3.2; UBCH10

Genbank Number:


1. Mondal, S. et al: A bioluminescent assay for monitoring conjugation of ubiquitin and ubiquitin-like proteins. Anal. Biochem. 510: 41-51, 2016

2. Rape, M. et al: Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432: 588-595, 2004

3. Townsley, F. M. et al: Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc. Nat. Acad. Sci. 94: 2362-2367, 1997

Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

21 kDa

Product Datasheets

There are no related publications available for this product.


Cancer, Cell Cycle, Neurobiology


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