Recombinant full-length human EIF2AK1 (HRI) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H07-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
H07-10G-05 | 5 ug | $226 | |
H07-10G-10 | 10 ug | $325 | |
H07-10G-BULK | BULK | Contact Us |
Overview:
EIF2AK1 (HRI) or eukaryotic translation initiation factor 2-alpha kinase 1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. EIF2AK1 (HRI) is a kinase that can be inactivated by hemin and is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-alpha (1). EIF2AK1 (HRI) is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. EIF2AK1 (HRI) functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia (2).
Gene Aliases:
HCR; HRI; KIAA1369
Genbank Number:
References:
1. Hwang. et.al: Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2-alpha kinase: down-regulated in epithelial ovarian cancers. Molec. Cells 10: 584-591, 2000.
2. Liu, S. et.al: The function of heme-regulated elF2-alpha kinase in murine iron homeostasis and macrophage maturation. J. Clin. Invest. 117: 3296-3305, 2007.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~120 kDa
Product Datasheets
There are no related publications available for this product.
Angiogenesis, Cellular Stress, Inflammation, Neurobiology, Ser/Thr Kinases
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