Recombinant full-length human ELOB was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. E30-34H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E30-34H-20 | 20 ug | $215 | |
E30-34H-50 | 50 ug | $435 | |
E30-34H-BULK | BULK | Contact Us |
Overview:
Elongin-B (ELOB) is a pivotal component of the Elongin complex involved in transcription elongation and a crucial subunit of the E3 ubiquitin-protein ligase complex. In the Elongin complex, ELOB acts as a stabilizing bridge between Elongin-A and Elongin-C, stabilizing the complex and enabling its functionality in transcription elongation in order to maintain proper gene expression. Furthermore, ELOB, as part of the E3 ligase complex, participates in protein degradation through the ubiquitin-proteasome pathway, influencing cellular homeostasis by regulating protein turnover.
Genbank Number:
References:
1. Aso T, et al. (1995). A molecular structure in the replication complex of foot-and-mouth disease virus for RNA synthesis. J Biol Chem, 270(23), 13576-13583.
2. Ivan M, et al. (2001). HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science, 292(5516), 464-468.
Purity:
Sample Purity. For specific information on a given lot, see related technical data sheet.
Alternative Name(s):
Elongin-B; TCEB2; SIII p18; RNA polymerase II transcription factor SIII subunit B
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~18 kDa. Calculated MW ~13 kDa
There are no related publications available for this product.
Cellular Stress
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