Epac pathway, RAP1 pathway activator
Catalog No. R46-905
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
R46-905-100 | 100 ug | $240 | |
R46-905-BULK | BULK | Contact Us |
Overview:
A potent, cell permeable Epac (exchange protein directly activated by cAMP) activator (1). Induces RAP1 activation and insulin secretion in pancreatic beta cell lines (2-5). Induces vascular relaxation in rate mesenteric artery (6). The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2’-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in the serum will cleave the acetoxymethyl ester and reduce cell permeability.
References:
1. MJ Vliem et al. Chembiochem. Sci.2008 9:2052.
2. OG Chepurny et al. J. Biol. Chem. 2009 284:10726.
3. GG Kelley et al. Islets 2009 1:260.
4. OG Chepurny et al. Am. J. Physiol. Edocrinol. Metab. 2010 298:E622.
5. I Dzhura et al Islets 2011 3:121.
6. OL Roberts et al. J. Physiol. 2013 591:5107.
CAS Registry Number:
1152197-23-3
Molecular Formula:
C20H21ClN5O8PS
Appearance:
White lyophilized solid
Melting Point:
N/A
Molecular Weight:
557.9
Purity:
>97% (HPLC)
Solubilization:
May be dissolved in DMSO (50 mg/ml). Poorly soluble in aqueous solution.
Aliases:
8-(4-Chlorophenylthio)-2'-O-methyladenosine-3', 5'-cyclic monophosphate acetoxymethyl ester
Storage and Stability:
Store desiccated as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 1 month.
Molecular Structure:
There are no related publications available for this product.
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