Recombinant human CK1 gamma 1 (21-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C68-11G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C68-11G-05 | 5 ug | $226 | |
C68-11G-10 | 10 ug | $325 | |
C68-11G-BULK | BULK | Contact Us |
Overview:
CK1γ1 or casein kinase 1, gamma 1 is belonging to the most abundant serine/threonine kinase in eukaryotic cell extracts which is mainly involved in growth and morphogenesis of eukaryotic cells. Casein kinase 1, gamma 1 possesses a C-terminal most terminal sequence motif (MTM), which it shares with CSNK1G2 and CSNK1G3 which is associated with heterologous carboxy-terminal sequences (1). Casein kinase 1-gamma couples Wnt receptor activation to the cytoplasmic signal transduction apparatus (2).
Gene Aliases:
CK1G1; CSNK1G1; CKI-gamma 1
Genbank Number:
References:
1. Kusuda, J. et.al: Cloning, expression analysis and chromosome mapping of human casein kinase 1 gamma-1 (CSNK1G1): identification of two types of cDNA encoding the kinase protein associated with heterologous carboxy-terminal sequences. Cytogenet. Cell Genet. 90: 298-302, 2000.
2. Davidson, G. et.al: Casein kinase 1-gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438: 867-872, 2005.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~70-76 kDa
R Chia et al., Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nature Communications December 2014 10.1038/ncomms6827
Zheng Y et al., Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase
scientific reports March 2019 10.1038/s41598-019-40950-7
A. Basta Holly et al., Encephalomyocarditis Virus Leader Is Phosphorylated by CK2 and Syk as a Requirement for Subsequent Phosphorylation of Cellular Nucleoporins Journal of Virology December 2013 10.1128/JVI.03150-13
Mamais Adamantios et al., Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution Journal of Biological Chemistry June 2014 10.1074/jbc.M113.528463
Cancer, Inflammation, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling
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