Recombinant full-length human tag-free 14-3-3epsilon was expressed in E. coli.
Catalog No. Y75-30N
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
Y75-30N-20 | 20 ug | $160 | |
Y75-30N-50 | 50 ug | $336 | |
Y75-30N-BULK | BULK | Contact Us |
Overview:
14-3-3ε, also known as tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein is a member of the 14-3-3 family. 14-3-3ε has been reported to be involved in heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK) pathways (1). 14-3-3ε interaction with the deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Association of 14-3-3ε, HSF1 with ERK during heat shock may modulate the amplitude of the response and control the termination of HSP expression on resumption of growth conditions (2).
Gene Aliases:
14-3-3 epsilon, YWHAE, MDS, MDCR, KCIP-1, 14-3-3E, FLJ45465
Genbank Number:
References:
1. Wang, X. et al: Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress.J. Biol. Chem. 2004; 279(47):49460-9.
2. Mizuno, E. et al: 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase.Exp Cell Res. 2007; 313(16):3624-34.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles
Molecular Weight:
~30 kDa
There are no related publications available for this product.
AKT/PKB Pathway, Cancer, Cell Cycle, Cellular Stress, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, WNT Signaling
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