OUTD7B is a deubiquitinylase that belongs A20 subgroup of ovarian tumor (OUT) protein superfamily. It plays an essential role in inflammation and proliferation pathways. (1) OTUD7B is involved in regulation of the non-canonical NF-NF-κB pathway. (2) Studies suggest role of OUTD7B in cancer and has been shown to promote lung cancer cell proliferation and migration via Akt/VEGF signal pathway. Therefore, strategies to silence OTUD7B in carcinoma tissues may provide insights into developing therapies against lung adenocarcinoma and squamous carcinoma. (3)
CEZANNE, ZA20D1, OTU deubiquitinase 7B
1. Cao L. et al. The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-kappaB pathway. J Cell Biochem. 119:1979–91 2018.
2. Hongbo H. et al. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature. 494:371–374, 2013.
3. Dan-dan L. Upregulation of OTUD7B (Cezanne) promotes tumor progression via AKT/VEGF pathway in lung squamous carcinoma and adenocarcinoma. Frontiers in Oncology. 9:862, 2019.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Neurobiology