Home   >    Enzymes   >   Ubiquitin Enzymes

BAP1, Active

Recombinant full-length human BAP1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Catalog No. B504-30H


Shop Online



Catalog No. Pack Size Price (USD)
B504-30H-05 5 ug $226
B504-30H-10 10 ug $325
B504-30H-BULK BULK Contact Us  


Overview:

BAP1 (BRCA1 associated protein-1) is a deubiquitinating enzyme belonging to the ubiquitin C-terminal hydrolase subfamily and is involved in the ubiquitin removal from proteins. It binds to the RING finger domain of the BCRA1 and acts as a tumor suppressor (1). BAP1 mutations have been found to cause multiple tumour types and high tumour phenotype penetrance, suggesting that it may have a major role in inducing cancer growth (2).


Gene Aliases:

HUCEP-13, KIAA0272, Hucep-6, UCHL2


Genbank Number:


References:


1. Carbone, Michele et al: BAP1 and cancer. Nature reviews. Cancer vol. 13,3: 153-9, 2013

2. Jensen, D.E. et al: BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene. 16,9: 1097–112, 1998.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

98 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


RELATED PRODUCTS


  DUB Reaction Buffer (4X), D01-09

  DUB Substrate I, U06-57


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox