Ubiquitin specific peptidase 14 (USP14) belongs to the ubiquitin-specific processing (UBP) family of proteases, and inhibits the degradation of ubiquitinated proteins as a proteasome-associated deubiquitinating enzyme (1). Altered expression of USP14 affects the chemotactic cell migration via CXCL12 mediated degradation of CXCR4 (2). USP14 is highly expressed in multiple myeloma (MM) cells than in its normal origin and the inhibition of USP14 can decrease the proliferation and the cell viability in MM (3).
1. Lee BH, et al. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 2010; 467 (7312): 179-184.
2. Mines MA, et al. Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK activation. J Biol Chem. 2009 Feb 27; 284(9):5742-52.
3. Tian Z, et al. novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple
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Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder