Home   >    Enzymes   >   Ubiquitin Enzymes

OTUD6B, Protein

Recombinant full-length human OTUD6B was expressed in E. coli cells using an N-terminal His tag.
Catalog No. O576-30H


Shop Online



Catalog No. Pack Size Price (USD)
O576-30H-20 20 ug $215
O576-30H-50 50 ug $435
O576-30H-BULK BULK Contact Us  


Overview:

OTU domain containing 6B (OTUD6B) belongs to the ovarian tumor domain containing subfamily of deubiquitinating enzymes (DUBs), which inhibit protein degradation mediated by ubiquitination through removing ubiquitin (1). OTUD6B regulates protein synthesis in non-small cell lung cancer (NSCLC) cells via mTORC1, cyclin D1, and c-Myc protein stability (2). It is reported that an intellectual disability syndrome is caused by the bialllelic pathogenic variants in OTUD6B (3).


Gene Aliases:

DUBA5; CGI-77; DUBA-5; IDDFSDA


Genbank Number:


References:


1. Sowa ME, et al. Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.

2. Sobol A, et al. Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation. Mol Cancer Res. 2017 Feb;15(2):117-127.

3. Santiago-Sim T, et al. Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. Am J Hum Genet. 2017 Apr 6;100(4):676-688.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

37 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Neurobiology



SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox