Carboxylesterase 2 (CES2) is a member of the carboxylesterase family, which catalyzes the hydrolysis transesterification of various xenobiotic and endogenous substrates with ester, thioester, or amide bonds to detoxify the xenobiotics and activate the prodrugs (1). CES2 is mainly expression in intestine to hydrolyze substrates with a large alcohol group and small acyl group such as aspirin, the anticancer prodrug irinotecan (CPT-11), and flutamide (2). In addition, CES2 is also involved in obesity and fatty liver disease, which is related in lipid metabolism (2).
iCE; CE-2; PCE-2; CES2A1
1. Redinbo, M. R. and P.M. Potter. Mammalian carboxylesterases: from drug targets to protein therapeutics. (2005) Drug Discovery Today, 10:313.
2. Lian J., Nelson R., Lehner R. Carboxylesterases in lipid metabolism: from mouse to human. Protein Cell 9:178-195(2018).
Sample Activity Plot. For specific information on a given lot, see related technical data sheet
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cardiovascular Disease, Metabolic Disorder