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CES2, Active

Recombinant full length human CES2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C302-30G


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Catalog No. Pack Size Price (USD)
C302-30G-05 5 ug $226
C302-30G-10 10 ug $325
C302-30G-BULK BULK Contact Us  


Overview:

Carboxylesterase 2 (CES2) is a member of the carboxylesterase family, which catalyzes the hydrolysis transesterification of various xenobiotic and endogenous substrates with ester, thioester, or amide bonds to detoxify the xenobiotics and activate the prodrugs (1). CES2 is mainly expression in intestine to hydrolyze substrates with a large alcohol group and small acyl group such as aspirin, the anticancer prodrug irinotecan (CPT-11), and flutamide (2). In addition, CES2 is also involved in obesity and fatty liver disease, which is related in lipid metabolism (2).


Gene Aliases:

iCE; CE-2; PCE-2; CES2A1


Genbank Number:


References:


1. Redinbo, M. R. and P.M. Potter. Mammalian carboxylesterases: from drug targets to protein therapeutics. (2005) Drug Discovery Today, 10:313.

2. Lian J., Nelson R., Lehner R. Carboxylesterases in lipid metabolism: from mouse to human. Protein Cell 9:178-195(2018).


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

90 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cardiovascular Disease, Metabolic Disorder



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