Recombinant human mutant EIF2AK4 (GCN2) pseudokinase domain (V379F) (260-539) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. E12-16G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
E12-16G-20 | 20 ug | $215 | |
E12-16G-50 | 50 ug | $435 | |
E12-16G-BULK | BULK | Contact Us |
Overview:
GCN2, or general control nonderepressible 2, is a conserved serine/threonine protein kinase crucial for cellular responses to amino acid deprivation. Activated by uncharged tRNAs during amino acid starvation, GCN2 phosphorylates eukaryotic initiation factor 2α (eIF2α), globally inhibiting protein synthesis and selectively translating mRNAs like ATF4. This pathway, identified in yeast and conserved in mammals, plays roles in immune responses, metabolic homeostasis, and the integrated stress response (ISR). Dysregulation of GCN2 is implicated in diseases, including metabolic disorders. The pathway's evolutionary conservation underscores its fundamental role in cellular stress responses.
Genbank Number:
References:
1. Hinnebusch AG. Annu Rev Microbiol. 2005;59:407-450.
2. Wek RC et al. Biochem Soc Trans. 2006;34(Pt 1):7-11.
3. Harding HP et al. Nature. 1999;397(6716):271-274.
4. Zaborske JM et al. J Biol Chem. 2009;284(37):25254-25267.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Alternative Name(s):
GCN2; KIAA1338
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Observed MW ~56 kDa. Calculated MW ~58 kDa.
There are no related publications available for this product.
Cancer, Cell Cycle, Cellular Stress
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