Overview:

The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), alternatively named Hypoxia-inducible factor (HIF)-1β, is part of the Hypoxia-inducible factor (HIF) pathway which mediates cellular adaptations to hypoxia and promotes tumour progression. Unlike HIF-1α that is regulated in an oxygen-dependent manner, HIF-1β is constitutively expressed. It has been shown that some tumour cells are capable to elevate HIF-1β in response to hypoxia to for a clonal advantage. HIF-1β binds HIF-1α, and forms the transcriptional active HIF-1 complex in the nucleus.

Gene Aliases:

ARNT; bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1BETA; TANGO

Genbank Number:

NM_001668

References:

1. Mandl M, et al: (2015). The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment. Radiat Oncol. 16;10:229.

2. Mandl M, et al (2013): Hypoxia-inducible factor-1β (HIF-1β) is upregulated in a HIF-1α-dependent manner in 518A2 human melanoma cells under hypoxic conditions. Biochem Biophys Res Commun. 26;434(1):166-72.