Recombinant full-length human Alpha-synuclein was expressed in E. coli cells using an N-terminal His tag and was phosphorylated by co-expression with PLK2 in vivo.
Catalog No. S22-54H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S22-54H-20 | 20 ug | $165 | |
S22-54H-50 | 50 ug | $251 | |
S22-54H-BULK | BULK | Contact Us |
Overview:
Alpha-synuclein is a member of the synuclein family which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain and alpha- and beta-synuclein selectively inhibit phospholipase D2 which is a highly conserved protein that is also abundant in neurons, especially presynaptic terminals (1). Alpha-synuclein gene is not a major risk factor in familial Parkinson disease (2). Alpha-synuclein may serve to integrate pre-synaptic signaling and membrane trafficking and Alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.
Genbank Number:
References:
1. Giasson, B. I. et.al: Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290: 985-989, 2000.
2. Markopoulou, K. et.al: Greek-American kindred with autosomal dominant, levodopa-responsive Parkinsonism and anticipation. Ann. Neurol. 38: 373-378, 1995.
Alternative Name(s):
NACP; PARK1; PARK4; PD1; SNCA
Storage and Stability:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Molecular Weight:
Observed MW ~19 kDa. Calculated MW ~18 kDa.
There are no related publications available for this product.
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