Rabbit Polyclonal Antibody
Catalog No. S22-62R
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S22-62R-100 | 100 ug | $795 | |
S22-62R-500 | 500 ug | $2395 | |
S22-62R-BULK | BULK | Contact Us |
Overview:
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
References:
1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).
2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.
3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.
4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.
5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.
6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
Specificity:
Detects ~14.46 kDa.
Cross Reactivity:
Human, Mouse, Rat
Host:
Rabbit
Immunogen:
Recombinant Human alpha Synuclein Fibril
Stability:
1yr at –20⁰C from date of shipment. Avoid freeze/thaw cycle.
Sample Data:
Western Blot analysis of Human Recombinant Protein showing detection of Alpha Synuclein protein using Rabbit Alpha Synuclein Polyclonal Antibody (Cat# S22-62R). Lane 1: MW ladder. Lane 2: Alpha Synuclein. Lane 3: Beta Synuclein. Lane 4: Gamma Synuclein. Alpha synuclein antibody shows cross-reactivity with beta synuclein but not gamma synuclein.
Sample Data:
Western blot analysis of Human Truncated Alpha Synuclein Portien showing detection of Alpha Synuclein protein using Rabbit Alpha Synuclein Polyclonal Antibody (Cat# S22-62R). Lane 1: MW ladder. Lane 2: hASYN aa 1-114 (5 µL).
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