Full-length recombinant human MATK (CTK) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M49-10G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
M49-10G-05 | 5 ug | $226 | |
M49-10G-10 | 10 ug | $325 | |
M49-10G-BULK | BULK | Contact Us |
Overview:
MATK belongs to tyrosine protein kinase family, CSK subfamily. It inactivates Src family kinase activity by specifically phosphorylating their C-terminal regulatory tyrosine residue and may plays a significant role in the signal transduction of hematopoietic cells (1). MATK binds to the phosphorylated Tyr568/570 sites on c-KIT to which FYN binds and leads to the down-regulation of FYN (2). MATK has been shown to be involved in signaling in some cases of breast cancer.
Gene Aliases:
CHK; CTK; HHYLTK; HYL; HYLTK; LSK
Genbank Number:
References:
1. Hirao A. et.al: Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. EMBO J. 16:2342-2351(1997).
2. Price D.J. et.al: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. J. Biol. Chem. 272:5915-5920(1997).
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~83 kDa
There are no related publications available for this product.
Cancer, Cytoplasmic Tyrosine Kinases
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