HDAC11 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC11 belongs to class IV of the histone deacetylase family that localizes to the nucleus and is involved in regulating the expression of interleukin 10 (1). HDAC11 expression is the highest in brain, heart, skeletal muscle, kidney and testis. HDAC11 control the DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression. HDAC11 has HDAC activity and this activity is inhibitable by trapoxin, an HDAC inhibitor (2). In coimmunoprecipitation experiments, HDAC11 interacts with HDA6.
1. Villagra, A. et al: The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol. 2009 Jan;10(1):92-100.
2. Gao, L. et.al: Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 277: 25748-25755, 2002.
Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Duan Wenwen et al., Design, Synthesis and Antitumor Evaluation of Novel Histone Deacetylase (HDAC) Inhibitors Equipped with Phenylsulfonylfuroxan Module as Nitric Oxide (NO) Donor Journal of Medicinal Chemistry May 2015 10.1021/acs.jmedchem.5b00317
Hou Xuben et al., Enhancing the Sensitivity of Pharmacophore-Based Virtual Screening by Incorporating Customized ZBG Features: A Case Study Using Histone Deacetylase 8 Journal of Chemical Information and Modeling March 2015 10.1021/ci500762z
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