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HDAC10, Active

Recombinant human HDAC10 (1-482) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. H92-31G


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Catalog No. Pack Size Price (USD)
H92-31G-05 5 ug $226
H92-31G-10 10 ug $325
H92-31G-BULK BULK Contact Us  


Overview:

HDAC10 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC10 belongs to class II of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the N-terminal tail of histones and represses transcription in large multiprotein complexes with transcriptional co-repressors (1). Therefore, HDAC10 plays a role in transcriptional repression. HDAC10 interacts with HDAC3 in co-transfected embryonic kidney cells (2). Deletion analysis indicates that both the N- and C-terminal domains of HDAC10 bound HDAC3 independently.


Gene Aliases:

DKFZp761B039; MGC149722


Genbank Number:


References:


1. Fischer, D. D. et.al: Isolation and characterization of a novel class II histone deacetylase, HDAC10. J. Biol. Chem. 277: 6656-6666, 2002.

2. Tong, J. J. et.al: Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 30: 1114-1123, 2002.


Specific Activity:

Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~77 kDa



Product Datasheets



Safety Datasheet



RESEARCH AREAS

Cancer, Cell Cycle, Inflammation


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