Anti-2019-nCoV Spike (P681H) Mutant
Polyclonal Antibody
Catalog No. C19S1-6701R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C19S1-6701R-20 | 20 ug | $165 | |
| C19S1-6701R-100 | 100 ug | $325 | |
| C19S1-6701R-BULK | BULK | Contact Us |
Polyclonal Antibody
Catalog No. C19S1-6701R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| C19S1-6701R-20 | 20 ug | $165 | |
| C19S1-6701R-100 | 100 ug | $325 | |
| C19S1-6701R-BULK | BULK | Contact Us |
Overview:
In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7, was discovered in the United Kingdom. This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery. The transmission of UK variant (B.1.1.7 lineage) was increased at least 50%. Increased severity and higher death rate were also found in UK variant. UK variant will not affect the effectiveness of COVID19 vaccine. One of the mutations associated with this lineage is a N501Y in the spike protein of the virus. It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence. B.1.1.7 viruses have also been shown to have a P681H in the cleavage site of spike protein. This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.
Sample Data:
ELISA Validation of P681H Mutant Specific Spike Antibodies with SARS-CoV-2 UK Variant Spike S1 Protein. Anti-2019-nCoV Spike P681H mutant specific antibody can specifically detect UK variant (B.1.1.7) spike S1 protein, but not WT spike S1 protein.
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Specificity:
Recognizes the 2019-nCoV spike protein (P681H)
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Cross Reactivity:
Virus
Concentration:
1mg/ml
References:
1) Duchene et al. Virus Evolution 6(2): veaa061. 2) Gu et al. Science 369(6511):1603-1607 3) Hoffmann et al. Molecular Cell 78(4):779-784.e5 4) Davies et al. Science 372(6538):eabg3055. 5) Davies et al. Nature. 593(7858):270-274. 6) Graham, et al. The Lancet Public Health. 6(5): e335-e345. 7) Horby et al. New & Emerging Threats Advisory Group. 2020;91:264-266.
Storage and Stability:
Stable at 4˚C for three months and -20˚C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
There are no related publications available for this product.
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