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Available in August:

BIRC3, Active
BIRC7, Active
HERC4, Active
RNF34 (CARP), Active
RNF34L (CARP2), Active
TRIM37, Active
UBA1 (UBE1), Active
UBE2A, Active
UBE2C, Active
UBE2D1 (UBCH5A), Active
UBE2D2 (UBC4), Active
UBE2D3 (UBCH5C), Active
UBE2E3 (UBCH9), Active
UBE2G1 (UBC7), Active
UBE2K (UBC1), Active
UBE2N (UBC13), Active
UBE2O, Active
WWP2, Active

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Product Perspective:
    Ubiquitin Enzyme System


Ubiquitin is a small highly conserved protein that is conjugated onto substrates in a process called ubiquitination. Poly-ubiquitination targets the substrate for destruction by the 26S proteasome. Besides ubiquitination-mediated proteasomal degradation, ubiquitin-signaling is also involved in regulating cell-cell interactions, intracellular targeting and gene expression. Ubiquitination is catalyzed in a stepwise manner by the three enzymes: E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating and E3 ubiquitin-protein ligase. First, E1 catalyzes the ATP-dependent conjugation of a sulfhydryl group to ubiquitin. Then, the ubiquitin is then transferred to the sulfhydryl group of E2 ubiquitin-conjugating enzyme. Finally, E3 catalyzes the transfer of ubiquitin from E2 to the target protein. Successive ubiquitin molecules can be linked to lysine 48 of the attached ubiquitin to form poly-ubiquitin chains, amplifying the protein degradation signal. Dysregulated ubiquitination is linked to various diseases such as Creutzfeldt-Jakob disease (CJD) and cervical cancer where insufficient proteolysis can lead to excess protein loads in neuronal tissue.

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