Overview:

Diacylglycerol kinase kappa (DGKK) is a member of the type II diacylglycerol kinase subfamily. Diacylglycerol kinases modulate the concentration of intracellular diacylglycerol by phosphorylating, producing phosphatidic acid (PA) (1). PA regulates signaling proteins, such as protein kinases and phosphatases, and can induce cell mitosis through regulation of growth factors (2). Genetic variants of DGKk are associated with hypospadias in mild and moderate Han Chinese cases (3).

Gene Aliases:

Diacylglycerol kinase kappa; DGK-kappa

Genbank Number:

NP_001013764.1

References:

1. Imai, S. et al: Identification and characterization of a novel human type II diacylglycerol kinase, DGK kappa. J Biol Chem. 2005; 280(48):39870-81.

2. Buckland, A.G. et al: Anionic phospholipids, interfacial binding and the regulation of cell functions. Biochim Biophys Acta. 2000; 1483(2):199-216.

3. Xie, H. et al: Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population. Asian journal of andrology. 2018; 20 (1): 85-89.