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DGKD, Active

Recombinant full-length human DGKD was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. D23-10G


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Catalog No. Pack Size Price (USD)
D23-10G-05 5 ug $226
D23-10G-10 10 ug $325
D23-10G-BULK BULK Contact Us  


Overview:

Diacylglycerol kinase delta (DGKD) is a member of DGK family type II which have a pleckstrin homology domain instead of the EF-hand motif in addition to two cysteine-rich regions (C1 domain) in the regulatory domain. These enzymes catalyze the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins such as protein kinase C isoforms and RAS guanyl nucleotide-releasing proteins and some transient receptor potential channels.(1) DGK delta is involved in cell proliferation and glucose metabolism, and has been associated with certain cancers, diabetes and epilepsy.(2)


Gene Aliases:

DGKdelta, DGKD-2, DAGKdelta


Genbank Number:


References:


1. Sakane, F. et al. (1997) Diacylglycerol kinase J. Biol. Chem. 29, 1139-1143.

2. Sakai, H. et al. (2012). Recent progress on type II diacylglycerol kinases: the physiological functions of diacylglycerol kinase, δ, η and κ their involvement in disease. J Biochem. 152(5):397-406.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

151 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, PKA/PKC Pathway


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