Overview:

SPHK2 is a member of the SPHK family and catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). Sphingolipid metabolism regulates proper uterine decidualization and blood vessel stability (1). SPHK2 is involved in the regulation of chemosensitivity by controlling ceramide formation and the downstream Akt pathway in human colon cancer cells. SPHK2 plays an important role in migration of MDA-MB-453 cells toward the ligand EGF. The N-terminal-extended form of SPHK2 has a role in serum-dependent regulation of cell proliferation and apoptosis (2).

Gene Aliases:

None

Genbank Number:

NM_020126

References:

1. Mizugishi, K. et al: Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J. Clin. Invest. 1172993-3006, 2007.

2. Hait, N. C.et al: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 3251254-1257, 2009. NoteErratumScience 326366 only, 2009.