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SPHK2, Active

Recombinant full-length human SPHK2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S18-102G


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Catalog No. Pack Size Price (USD)
S18-102G-05 5 ug $259
S18-102G-10 10 ug $380
S18-102G-BULK BULK Contact Us  


Overview:

SPHK2 is a member of the SPHK family and catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). Sphingolipid metabolism regulates proper uterine decidualization and blood vessel stability (1). SPHK2 is involved in the regulation of chemosensitivity by controlling ceramide formation and the downstream Akt pathway in human colon cancer cells. SPHK2 plays an important role in migration of MDA-MB-453 cells toward the ligand EGF. The N-terminal-extended form of SPHK2 has a role in serum-dependent regulation of cell proliferation and apoptosis (2).


Gene Aliases:

None


Genbank Number:


References:


1. Mizugishi, K. et al: Maternal disturbance in activated sphingolipid metabolism causes pregnancy loss in mice. J. Clin. Invest. 1172993-3006, 2007.

2. Hait, N. C.et al: Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 3251254-1257, 2009. NoteErratumScience 326366 only, 2009.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~110 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Invasion/Metastasis, Lipid Kinases, Neurobiology, PKA/PKC Pathway


RELATED PRODUCTS


  Kinase Assay Buffer III, K03-09


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