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PIP5K3 (PIKFYVE), Active

Recombinant human PIP5K3 (1400-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P17-112BG


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Catalog No. Pack Size Price (USD)
P17-112BG-05 5 ug $259
P17-112BG-10 10 ug $380
P17-112BG-BULK BULK Contact Us  


Overview:

PIP5K3 (also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) encodes an enzyme that phosphorylates the D-5 position in PtdIns and phospha-tidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns (3,5)biphosphate. PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol but also have protein kinase activity (1). PIP5K3 regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. The inhibition of PIP5K3 renders the late endosome /lysosome compartment refractory to fusion with autop-hagosomes and multivesicular bodies (2).


Gene Aliases:

PIKFYVE; CFD; FAB1; PIP5K; FLJ37746; KIAA0981; MGC40423


Genbank Number:


References:


1. Shisheva, A..et.al: Cloning, characterization, and expression of a novel Zn(2+)-binding FYVE finger-containing phosphor-inositide kinase in insulin-sensitive cells. Molec. Cell. Biol. 19: 623-634, 1999.

2. de Lartigue, J.et.al: PIKfyve regulation of endosome-linked pathways. Traffic 10: 883-893, 2009.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

110 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling


RELATED PRODUCTS


  Lipid Kinase Buffer, L01-09

  PI(3)P:PS, P426-59


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