Home   >    Enzymes   >   Kinases

PIP4K2B, Active

Recombinant full-length human PIP4K2B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P76-102BG


Shop Online



Catalog No. Pack Size Price (USD)
P76-102BG-05 5 ug $259
P76-102BG-10 10 ug $380
P76-102BG-BULK BULK Contact Us  


Overview:

PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase, type II, beta) catalyzes the phosphorylation of phospha-tidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. PIP4K2B is a member of the phosphatidylinositol-5-phosphate 4-kinase family. PIP5K2B interacts specifically with the juxtamembrane region of the p55 TNF receptor and that PIP5K2B activity is increased in mammalian cells by treatment with TNF-alpha (1). PIP5P4KB plays a role in determining insulin sensitivity and adiposity (2).


Gene Aliases:

PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta


Genbank Number:


References:


1. Castellino. et.al: A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. J. Biol. Chem. 272: 5861-5870, 1997.

2. Lamia, K. A. et.al: Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta -/- mice. Molec. Cell. Biol. 24: 5080-5087, 2004.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

73 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Lipid Kinases, Metabolic Disorder, Neurobiology, NfkB Pathway, WNT Signaling


RELATED PRODUCTS


  Lipid Kinase Buffer, L01-09

  MnCl2 Solution, M40-09

  PI(5)P:PS, P428-59


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox