Overview:

PIK3C3 or phosphoinositide-3-kinase is a member of the PI 3-kinase family that mediates the active diversion of proteins from the secretory pathway to vacuoles. PIK3C3 are involved in both receptor-mediated signal transduction and intracellular trafficking. In yeast, the vps34 gene product is a PI 3-kinase. PIK3C3 has a substrate specificity and ion requirements that are distinct from the other known mammalian PI 3-kinases (1). PIK3C3 mediate catalysis on membranes and suppress futile adenosine triphosphatase cycles. PIK3C3 appears to alternate between a closed cytosolic form and an open form on the membrane (2).

Gene Aliases:

VPS34, hVps34, MGC61518

Genbank Number:

NM_002647

References:

1. Volinia, S. et.al: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14: 3339-3348, 1995.

2. Miller, S. et.al: Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 327: 1638-1642, 2010.