LOXL2 is a member of the lysyl oxidase gene family which is essential for the biogenesis of connective tissue. LOXL2 encodes an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. LOXL2 may play an important role in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family (1). LOXL2 may mediate fibroblast activation through enzymatic crosslinking of fibrillar collagen and local matrix tention, resulting in activation of TGF1 signaling (2).
1. Jourdan-Le Saux, C.et.al: The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. J. Biol. Chem. 274: 12939-12944, 1999.
2. Barry-Hamilton, V. et.al: Allosteric inhibition of lysyl oxidase-like-2 impedes the development of pathologic microenvironment. Nature Med. 16: 1009-1017, 2010.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Msarcu L et al., Non‐destructive detection of matrix stabilization correlates with enhanced mechanical properties of self‐assembled articular cartilage Journal of tissue engineering and regenerative medicine April 2019 10.1002/term.2824
Athanasiou KA et al., Functional self-assembled neocartilage as part of a biphasic osteochondral construct PLoS One April 2018 10.1371/journal.pone.0195261 Free full text
K. Murphy Meghan et al., Neocartilage integration in temporomandibular joint discs: physical and enzymatic methods Interface December 2014 10.1098/rsif.2014.1075
Cancer, Metabolic Disorder