LOXL4 or lysyl oxidase-like 4 is a member of the lysyl oxidase family of amine oxidases. LOXL4 catalyzes the final enzymatic step required for the lysine-derived crosslinks essential for the formation of collagen fibrils and insoluble elastic fibers within the extracellular matrix (1). LOXL4 can also contribute to developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis. LOXL4 is highly expressed in skeletal muscle, testis, and pancreas (2).
1. Asuncion, L.et.al: A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain. Matrix Biol. 20: 487-491, 2001.
2. Maki, J. M. et.al: Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains. Matrix Biol. 20: 493-496, 2001.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Cancer, Metabolic Disorder