Home   >    Proteins   >   Protein Kinases

MNK2, Active

Recombinant full-length human MNK2 was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. M55-10G


Shop Online



Catalog No. Pack Size Price (USD)
M55-10G-05 5 ug $226
M55-10G-10 10 ug $325
M55-10G-BULK BULK Contact Us  


Overview:

MNK2 (MAP kinase-interacting kinase 2) contains a conserved C-terminal ERK-interacting domain, a catalytic domain with homology to the calcium/calmodulin-dependent family of kinases, and putative MAP kinase phosphorylation sites located within the T loop of the kinase domain. MNK2 binds tightly to the growth factor-regulated MAP kinases, ERK1 and ERK2. ERK and p38 phosphorylate MNK2, which stimulates its in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E) (1). A yeast two-hybrid screen showed the Mnk2 protein interacted with the ligand-binding domain of estrogen receptor beta (ERbeta) (2).


Gene Aliases:

MKNK2; GPRK7


Genbank Number:


References:


1. Waskiewicz, A J. et al: Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 1997 Apr 15;16(8):1909-20.

2. Slentz-Kesler, K. et al: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. Genomics. 2000 Oct 1;69(1):63-71.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~74 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Angiogenesis, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, p38 Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  RSK2, Active, R17-10G

  TIE2, Active, T04-11G

  AMPK (A1/B1/G2), Active, P55-10H

  MEK2, Unactive, M03-14G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox