Overview:

PP1A is a serine/threonine specific protein phosphatase family which is involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. PP1A is one of the three catalytic subunits of protein phosphatase 1 (PP1) (1). PP1A functions as a suppressor of learning and memory and as a potential mediator of cognitive decline during aging (2).PP1A is also play a main role in splice site selection and is an important regulator of cardiac function.

Gene Aliases:

PP-1A, PPP1A, PPP1CA, MGC1674, MGC15877

Genbank Number:

NM_002708

References:

1. Cohen, P.et.al: Protein phosphatases come of age. J. Biol. Chem. 264: 21435-21438, 1989.

2. Genoux, D. et.al: Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418: 970-975, 2002.