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HSF1 Protein

Recombinant full length human HSF1 was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. H25-30G


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Catalog No. Pack Size Price (USD)
H25-30G-50 50 ug $435
H25-30G-20 20 ug $215
H25-30G-BULK BULK Contact Us  


Overview:

HSF1 is a member of the heat shock transcription factor family. Protein-damaging stress lead to the activation of HSF1 which binds to upstream regulatory sequences in the promoters of heat shock genes leading to enhanced heat shock gene expression (1). The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. HSF1 activity is regulated at different levels by heat shock proteins and co-chaperones and is modulated further by a number of mechanisms involving other stress-regulated aspects of cell metabolism (2).


Gene Aliases:

HSTF1


Genbank Number:


References:


1. Pirkkala, L. et al: Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J. 2001 May;15(7):1118-31.

2. Voellmy, R.: Feedback regulation of the heat shock response. Handb Exp Pharmacol. 2006;(172):43-68.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~96 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway


RELATED PRODUCTS


  HSP10 Protein, H29-54G

  HSP90 beta Protein, H36-54H

  14-3-3 epsilon Protein, Y75-30N

  Anti-HSF1, H25-63R


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