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STAT3 Protein

Recombinant full-length human STAT3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S54-54G


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Catalog No. Pack Size Price (USD)
S54-54G-50 50 ug $435
S54-54G-20 20 ug $215
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Overview:

STAT3 is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT3 is widely expressed and becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to a variety of stimuli such as EGF, IL-6, PDGF, IL-2 and G-CSF (1). This phosphoprotein forms homodimers as well as heterodimers with other members of the STAT family and translocate to the nucleus in order to modulate the transcription of various genes (2).


Gene Aliases:

APRF, FLJ20882, MGC16063


Genbank Number:


References:


1. Zhong, Z. et al: Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science. 1994 Apr 1;264(5155):95-8.

2. Tian, S. S. et al: Rapid activation of the STAT3 transcription factor by granulocyte colony-stimulating factor. Blood. 1994 Sep 15;84(6):1760


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~120 kDa



 Yamamoto Masahiro et al., A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3 Journal of Experimental Medicine November 2009 10.1084/jem.20091703

 K. Urlam Murali et al., Development of new N-arylbenzamides as STAT3 dimerization inhibitors Medicinal Chemistry Communication April 2013 10.1039/C3MD20323A

 Kim Daejin et al., A specific STAT3-binding peptide exerts anti-proliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling Cancer Research February 2014 10.1158/0008-5472.CAN-13-2187

 Zhang Xiaolei et al., A novel inhibitor of STAT3 homodimerization selectively suppresses STAT3 activity and malignant transformation Cancer Research January 2013 10.1158/0008-5472.CAN-12-3175

 Li Zhi et al., Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent Journal of Immunology March 2013 10.4049/jimmunol.1203118

 Zhang L et al., Antitumor activity of novel pyrazole-based small molecular inhibitors of the STAT3 pathway in patient-derived high-grade glioma cells. PLoS One July 2019 10.1371/journal.pone.0220569

 Jin Jeon Young et al., Role of NEK6 in Tumor Promoter-induced Transformation in JB6 C141 Mouse Skin Epidermal Cells Journal of Biological Chemistry September 2010 10.1074/jbc.M110.137190

 CC Arpin et al., Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics Molecular Cancer Therapeutics May 2016 10.1158/1535-7163.MCT-15-0003

 D. G. Page Brent et al., Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma Journal of Medicinal Chemistry August 2013 10.1021/jm3017255

 Mazouchia Amir et al., On the performance of bioanalytical fluorescence correlation spectroscopy measurements in a multiparameter photon-counting microscope Analytica Chimica Acta February 2011 10.1016/j.aca.2011.01.002

 A. Cumaraswamy Abbarna et al., Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein ACS Medical Chemistry Letters September 2014 10.1021/ml500165r

 Giri Shailendra et al., Preclinical Therapeutic Potential of a Nitrosylating Agent in the Treatment of Ovarian Cancer PLoS One June 2014 10.1371/journal.pone.0097897

 Kinoshita Takayoshi et al., Knowledge-Based Identification of the ERK2/STAT3 Signal Pathway as a Therapeutic Target for Type 2 Diabetes and Drug Discovery Chemical Biology & Drug Design July 2011 10.1111/j.1747-0285.2011.01151.x

 Zeidan N et al., Magnetic bead-based electrochemical detection of interaction between epigallocatechin-3-gallate and STAT proteins Analytical Methods March 2015 10.1039/c5ay00169b

 Salvatore Badali Daniel et al., Development of STAT3 as an accessible target for fluorescence-based inhibition assays Journal of Undergraduate Life Sciences May 2010

 Danielle Croucher et al., Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Thesis; University of Toronto July 2013 10.1016/j.bbcan.2013.12.005


RESEARCH AREAS

Apoptosis/Autophagy, Cancer, ERK/MAPK Pathway, Inflammation, JAK/STAT Pathway


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