Anti-RSK1
Rabbit Polyclonal Antibody
Catalog No. R15-63R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R15-63R-25 | 25 ug | $115 | |
| R15-63R-100 | 100 ug | $395 | |
| R15-63R-BULK | BULK | Contact Us |
Rabbit Polyclonal Antibody
Catalog No. R15-63R
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| R15-63R-25 | 25 ug | $115 | |
| R15-63R-100 | 100 ug | $395 | |
| R15-63R-BULK | BULK | Contact Us |
Overview:
RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue (1). RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation (2).
References:
1. Moller, D E. et al: Human rsk isoforms: cloning and characterization of tissue-specific expression. Am. J. Physiol. 266: C351-C359, 1994.
2. Gross, S D. et al: Induction of metaphase arrest in cleaving Xenopus embryos by the protein kinase p90(Rsk). Science 286: 1365-1367, 1999.
Specificity:
Anti-RSK1 antibody recognizes the RSK1 protein.
Cross Reactivity:
RSK1 from Human, Mouse, Rat
RSK1 from other species may also be detectable.
Host:
Rabbit
Immunogen:
C-LAQRRVRKLPSTTL peptide KLH conjugates
Purification:
Affinity purified by peptide C-LAQRRVRKLPSTTL on agarose from rabbit serum
Stability:
Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For optimal performance, avoid repeated handling and multiple freeze/thaw cycles.
Sample Data:
Representative western blot (1:2000) using 5µg, 10µg, and 20µg of from HeLa cell lysate.
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MJ Lommel et al., L-plastin Ser5 phosphorylation breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway. FASEB Journal March 2016 10.1096/fj.15-276311
Yanga Shuping et al., Phosphorylation of KIBRA by the extracellular signal-regulated kinase (ERK)?ribosomal S6 kinase (RSK) cascade modulates cell proliferation and migration Cellular Signaling February 2014 10.1016/j.cellsig.2013.11.012
M. Reipas Kristen et al., Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1). Oncotarget February 2014 10.18632/oncotarget.834
A. Everley Robert et al., Increasing Throughput in Targeted Proteomics Assays: 54-Plex Quantitation in a Single Mass Spectrometry Run Analytical Chemistry May 2013 10.1021/ac400845e
A. Galana Jacob et al., Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3 PNAS April 2014 10.1073/pnas.1405601111
Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Neurobiology, NfkB Pathway
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