Overview:

c-MER is a member of the TYRO3/AXL/MER (TAM) receptor kinase family which encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses (1). c-MER is essential regulators of mammalian spermatogenesis (2). Mutations in c-MER gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Gene Aliases:

MERTK

Genbank Number:

NM_006343

References:

1. Rothlin, C. V.et.al: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.

2. Lu, Q.et.al: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728, 1999.