Recombinant human c-KIT (T670I) (544-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C06-12FG
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
C06-12FG-05 | 5 ug | $226 | |
C06-12FG-10 | 10 ug | $325 | |
C06-12FG-BULK | BULK | Contact Us |
Overview:
c-KIT (T670I) is a protein that belongs to the type I cytokine receptor family which combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo (1). c-KIT (T670I) is a good candidate gene and the mutation of this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias (2).
Gene Aliases:
PBT, SCFR, CD118
Genbank Number:
References:
1. Gearing, D. P. et.al: The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13. Genomics 18: 148-150, 1993.
2. Dagoneau, N. et.al: Null leukemia inhibitory factor receptor (LIFR) mutations in Stuve-Wiedemann/Schwartz-Jampel type 2 syndrome. Am. J. Hum. Genet. 74: 298-305, 2004.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~73 kDa
Cancer, Inflammation, Neurobiology, Receptor Tyrosine Kinases
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