Overview:

DNAJB1-PRKACA is a chimeric fusion between the catalytic subunit alpha (PRKACA) of protein kinase A and the J-domain of the heat shock protein 40 (DNAJB1). A single segmental genetic deletion in one copy of chromosome 19 combines the first exon of DNAJB1 with exon 2 through 10 of PRKACA and results in the chimeric gene DNAJB1-PRKACA (1). Fusion kinase, DNAJB1-PRKACA is implicated in development of Fibrolamellar Hepatocellular Carcinoma (FL-HCC), thus is a potential oncogenic factor and a candidate drug target for FL-HCC (2).

Gene Aliases:

DNAJB1: Hsp40, DNAJ1
PRKACA: PKACA, PPNAD4

Genbank Number:

NM_006145
NM_002730

References:

1. Honeyman, J N. et al: Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma. Science 343: 1010-1014, 2014.

2. Kastenhuber, E R. et al: DNAJB1–PRKACA fusion kinase interacts with β- and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma. PNAS 14(50): 13076-13084, 2017.