Overview:

Wild-type p53-induced phosphatase 1 (WIP1) is a member of the PP2C family of Ser/Thr protein, and is highly expressed in testis and ovary (1). The expression of WIP1 is induced in responses to the environmental stresses (2). WIP1 dephosphorylates CHK2 at Thr-68 in as a negative regulator in the response of DNA damage (2). WIP1 suppresses the DNA double strand break repair by dephosphorylating the phosphorylated Ser-139 in a histone variant gamma-H2AX (3).

Gene Aliases:

PPM1D; JDVS; IDDGIP; PP2C-DELTA

Genbank Number:

BC016480

References:

1. Fiscella M. et. al: Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. PNAS. 1997 Jun 10; 94(12):6048-53.

2. Yoda A. et. al: Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. J Biol Chem. 2006 Aug 25; 281(34):24847-62.

3. Moon S. H. et. al: Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem. 2010 Apr 23; 285(17):12935-47.