Recombinant human fusion STRN (1-137a.a., exons1-3) - ALK (1058a.a.-end, exons20-29) protein was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A19-19JG
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| A19-19JG-05 | 5 ug | $435 | |
| A19-19JG-10 | 10 ug | $655 | |
| A19-19JG-BULK | BULK | Contact Us |
Overview:
Anaplastic large cell lymphomas are associated with chromosomal aberrations involving the anaplastic lymphoma kinase (ALK) gene, resulting in the expression of novel chimeric ALK proteins with transforming properties. Many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types (1). A fusion protein of STRN-ALK has been reported in a non-small cell lung cacner due to resistant to Alectinib (2).
Gene Aliases:
STRN: PPP2R6A; SG2NA; STRN1
ALK: ALK (Ki-1), CD246
References:
1. Palmer R H, et al: Anaplastic lymphoma kinase: signalling in development and disease. Biochem J. 2009 May 27;420(3):345-61.
2. Nakanishi Y, et al: Case Report of Non-Small Cell Lung Cancer with STRN-ALK Translocation: A Nonresponder to Alectinib. J Thorac Oncol. 2017 Dec;12(12):e202-e204.
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
110 kDa
There are no related publications available for this product.
Cancer
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