Overview:

Fms-related tyrosine kinase 3 (FLT3) is a gene that encodes for a tyrosine kinase that activates pathways in hematopoietic cells important in cellular proliferation. FLT3 is frequently mutated in acute myeloid leukemia (AML), myelodysplastic syndromes, other hematologic malignancies, and colorectal cancer. FLT3 mutations are observed in 24.3% of AML, of which internal tandem duplications (ITD) are the most frequent. FLT3 ITD occurs when sequences of less than ten to several hundred bases in length are repeated within the juxtamembrane domain are always “in-frame”.

Gene Aliases:

FLT3-ITD, FLT3 (L610_E611insCSSDNEYFYVDFREYEYDLKWEF-PRENL), FLK2, STK1, CD135

Genbank Number:

NM_004119

References:

1. http://www.mycancergenome.org/content/disease/acute-myeloid-leukemia/flt3/277/

2. Fathi AT, et al: Treatment of FLT3-ITD acute myeloid leukemia. Am J Blood Res. 1(2):175-89, 2011