Overview:

RET/PTC3 is fused of RET and the activating NCOA4 gene by intrachromosomal paracentric inversions in chromo-some 10 (1). Likes RET/PTC1, it is the most frequent RET rearrangements in papillary thyroid carcinoma (PTC) (2), especially in radiation-induced tumours. The RET/PTC3 rearrangements may be typical for radiation-induced childhood PTC with a short latency period (3). The RET/PTC rearrangements also have been shown in benign thyroid lesions, including Hashimoto's thyroiditis (HT).

Gene Aliases:

NCOA4: ELE1, RFG, ARA70, PTC3, DKFZp762E1112 RET: CDHF12, RET51, PTC, RET-ELE1; RET/PTC3

Genbank Number:

BC001562
NM_020630

References:

1. Santoro M, et al: Molecular characterization of RET/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene 1994, 9:509-516.

2. Nikiforov YE: RET/PTC rearrangement in thyroid tumors. Endocr Pathol 2002, 13:3-16.

3. Smida J. et al: Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus. Int J Cancer 1999, 80:32-38.