Recombinant mouse KDM5B (1-753) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. K425-31BG
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| K425-31BG-20 | 20 ug | $215 | |
| K425-31BG-50 | 50 ug | $435 | |
| K425-31BG-BULK | BULK | Contact Us |
Overview:
KDM5B is a lysine (K)-specific demethylase 5B which is highly expressed in testis and shows the lowest expression in skeletal muscle (1). KDM5B is a histone H3 lysine 4 (H3K4) demethylase up-regulated in prostate cancer and associated with androgen receptor where it regulated its transcriptional activity in reporter gene assays (2). Overexpression of KDM5B in HeLa cells results in loss of tri-, di-, and monomethyl H3K4, but does not alter the methylation status of H3K9 or H3K36. A KDM5B containing highly conserved putative DNA/chromatin binding motif is specifically up-regulated in breast cancer.
Gene Aliases:
Jarid1b;PUT1;Plu1;PLU-1;Rb-Bp2; AW556288; RBBP2H1A; mKIAA4034
Genbank Number:
References:
1. Kashuba, V. et.al: Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). Europ. J. Hum. Genet. 8: 407-413, 2000.
2. Xiang, Y. et.al: JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Nat. Acad. Sci. 104: 19226-19231, 2007.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~112 kDa
There are no related publications available for this product.
Cancer, Cell Cycle, Inflammation
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