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PKC eta, Active

Recombinant full-length human PKCeta was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. P67-10G


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Catalog No. Pack Size Price (USD)
P67-10G-05 5 ug $160
P67-10G-10 10 ug $226
P67-10G-BULK BULK Contact Us  


Overview:

PKCη is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCη is predominantly expressed in squamous cell epithelia and induces terminal differentiation of keratinocytes. PKCη that is endogenously expressed or overexpressed is found to associate with the cyclin E/cdk2/p21 complex in keratinocytes of mice and humans (1).


Gene Aliases:

PKCL; PKC-L; PRKCL; MGC5363; MGC26269; nPKC-eta, PRKCH


Genbank Number:


References:


1. Kashiwagi, M. et al: PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes. Oncogene. 2000 Dec 14;19(54):6334-41.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~103 kDa



RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, NfkB Pathway, PKA/PKC Pathway, Ser/Thr Kinases


RELATED PRODUCTS


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  PKC gamma, Active, P66-10G

  Anti-PKC delta, P64-63CR


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